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Patients transitioning to semaglutide from tirzepatide should begin with the lowest possible dose of semaglutide (0.25 mg weekly), regardless of their previous tirzepatide dosage

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[1] [2] It slows gastric emptying, increases feelings of fullness, and reduces hunger signals in the brain

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for subcutaneous semaglutide and tirzepatide in a large cohort study or subcutaneous semaglutide and liraglutide in a randomized trial (25, 26)
