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Clinical Implications of the 7-Day Half-Life The seven-day half-life has several important clinical implications beyond just dosing convenience
Using sterile water in a multi-dose vial significantly increases the risk of infection
[cited 2026 Jan 1]
However, their utility in other conditions, such as schizophrenia, cocaine addiction, and dementia, remains unsupported by robust evidence
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Additionally, their accuracy is diminished in cases of acute hepatitis, cholestasis, recent food ingestion, congestive heart failure, and severe obesity [50,51]
