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Each dose level requires a minimum of one month before moving up

In the skeletal muscle of obese and diabetic patients, a significant reduction in MFN2 expression has been correlated with impaired glucose oxidation and insulin resistance (Rizzuto et al., 2009)

However, if the pen was unopened and should have been refrigerated, or if temperatures exceeded 30C, the medication may be compromised and should be discarded

Patel L, Cooper CD, Quinton ND, Butler GE, Gill MS, Jefferson IG, et al

Starting low and going slow is the standard practice for both indications

Gradual dose escalation allows healthcare providers to monitor how each patient responds before making adjustments