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A separate randomized trial found that combining semaglutide with metformin outperformed metformin alone producing greater weight loss, improved insulin sensitivity, better cycle regularity, and higher rates of natural pregnancy

Bruising comes from the injection needle damaging small blood vessels, not from semaglutide itself

Reset Strategies: Dose Optimization and Lifestyle Interventions The first and most direct reset strategy is dose evaluation

If after one month a patient wishes to explore combination therapy or switch to oral tirzepatide, the medical team can facilitate that transition without interrupting continuity of care