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Sharma D, Verma S, Vaidya S, Kalia K, Tiwari V (2018) Recent updates on GLP-1 agonists: current advancements & challenges

While the opportunity for oral GLP-1s is substantial, realising its full potential will depend on how effectively pharmaceutical companies and CDMOs navigate the associated challenges

Heavyweights including Amgen and Pfizer are on the list of aspiring players, as well as smaller companies including Carmot Therapeutics, Structure Therapeutics, Zealand Pharma, Altimmune, Regor Therapeutics, and Vivani Medical

Its active ingredient is semaglutide, which belongs to the class of drugs called GLP1 receptor agonists

Mean basal insulin dose is 0.2 U/kg/d at near normal glycaemia for type 1 or 2 diabetes on continuous subcutaneous insulin infusion or oncenightly basal insulin