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People who are underweight or experiencing rapid unintended weight loss

4 A history of gallbladder disease A 2022 systematic review of 76 randomised trials found that GLP-1 medications are associated with a relative risk of around 37% for gallbladder or biliary disease, with a higher relative risk in weight-loss trials than in diabetes trials

The signals most often discussed are: In clinical trials involving people with diabetes, retinal complications were more frequent in those who already had retinopathy
Because the prevalence of CVD in the population with T2DM is around 32% [33], at least one fourth of the average patient with T2DM is possible a candidate for the use of the GLP-1RA, or sodium-glucose transporter-2 inhibitors [34], to improve the MACE outcome

10.1002/med.20142 21 MohsinS.BaniyasM
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The once-daily oral administration of oral semaglutide could also potentially improve adherence versus a once-daily injectable, but these data are challenging to incorporate into health economic analyses due to the uncertain impact on costs and effects
