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Nutrients in the gut lumen, including glucose, fatty acids, and amino acids, stimulate GIP secretion, rapidly increasing its circulating levels (Brown & Dryburgh 1971, Jorsal et al

Japan: Demand for GLP-1 receptor agonists in Japan is projected to rise at 6.4% CAGR through 2036

Liver Int 26(8): 1015-17 Wettergren A et al (1998): Glucagon-like peptide-1 inhibits gastropancreatic function by inhibiting central parasympathetic outflow

Towards a brighter future for millions of patients Given the growing global prevalence of T2D and obesity, the implementation of sublingual formulations could have profound implications for public health

Back Lasker Foundation (2024) 'GLP-1-based therapy for obesity'

The effect of semaglutide subcutaneous injection at 2.4 mg per week in patients with HFpEF and obesity (BMI 30 kg/m 2 ) but without diabetes was tested in STEP-HFpEF [29]