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Obesity remains a pressing public health concern, impacting millions of individuals worldwide and leading to severe health complications like diabetes, cardiovascular diseases, and even certain cancers (World Health Organization)

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A random-effects model was used to pool hazard ratios (HRs) and 95% confidence intervals (CIs)

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However, DPP-4 inhibitors have not reduced the risk of major adverse cardiovascular events, possibly because potentiation of SDF-1 enhances plaque growth and instability, activates deleterious neurohormonal mechanisms, and promotes cardiac inflammation and fibrosis