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PKA directly phosphorylates sulfonylurea receptor 1 (SUR1), a regulatory subunit of voltage-dependent K + channels and KATP channels, increasing membrane depolarization and voltage-gated Ca 2+ channel activation

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The sheer scale of demand has strained supply chains: even market leaders like Novo Nordisk (Wegovy, Ozempic) and Eli Lilly (Mounjaro, Zepbound) have increased production capacity aggressively