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Why it matters: GLP-1s have been incredibly popularand theyre reshaping consumer spending habits

New or worsening cognitive symptoms after starting a GLP-1 medication require prompt evaluation

2023;381:eadh0301
Abstract Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used treatments for patients with type 2 diabetes mellitus (T2DM)
GLP-1 medications can help: Weight loss from these medications reduces sleep apnea severity Studies show they can reduce the Apnea-Hypopnea Index (AHI) by 12-15 events per hour Tirzepatide reduced AHI by 48-56% compared to placebo Since OSA is both a cause and consequence of other health problems, improving sleep breathing can create a cascade of health benefits

Specifically, prolonged GLP-1RA administration (13 years or longer) has been associated with elevated thyroid cancer risk in certain populations [4], while high concentrations of liraglutide (100 nM) have been demonstrated to promote breast cancer progression via the NOX4/ROS/VEGF signaling pathway [18]
