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Ongoing and future trials are investigating whether these drugs can benefit brain health, especially when used before cognitive symptoms appear

For the receptor mechanism that underlies this work, see how the GLP-1 receptor is structured and signals, and for how discovery connects to the wider therapeutic landscape, the full picture of GLP-1 and metabolic disease

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Similarly, the trend remained unchanged in the stratified analysis according to the status of comorbidities, including MASH, LC, heart failure, T2D and CKD

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