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~24% 29% (Phase 3 data)

Since these medications have established safety profiles in approved metabolic indications, researchers feel they could potentially be repurposed for addiction treatment more quickly than entirely new drugs, although safety and tolerability in people with alcohol or substance use disorders still require dedicated testing

Furthermore, ongoing research endeavors are needed to further elucidate the long-term efficacy, safety, and tolerability of semaglutide in UC management, as well as its potential role in combination therapy and personalized treatment approaches

What this means practically is that oral contraceptives may be less effective during the dose escalation phase of retatrutide, when gastric emptying is most affected

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