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There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or normal distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets. Its proponents will state that hCG enhances compliance as it reduces side effects of VLCD and increases the patients basal metabolic rate

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These doses are both approximately 4-times the maximum recommended human dose of 2,000 mg based on body surface area comparisons

TNF-: Tumor Necrosis Factor-alpha