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This should be your foundational care, regardless of whether you try GLP-1 medications

Eligible patients lost an average of 13.6% of their body weight (-31.3 pounds) in a 64week clinical trial evaluating 25 mg oral semaglutide compared to those on 2.4mg injectable semaglutide who lost an average of 14.9% (-33.6 pounds) in a 68week clinical trial

HF patients frequently experience low mood, depression and cognitive impairment, with worse estimates shown for the HFpEF phenotype

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For many individuals, meaningful benefit may require long-term or lifelong use, similar to other maintenance medications used in chronic conditions