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Beyond easing manufacturing cost and supply pressure, this also reduces the metabolic load on the liver, a factor linked to tolerability challenges in this class

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11 A study has shown that GLP-1Rs are increased in the visceral adipose tissue of morbidly obese patients with insulin resistance

These differences suggest that activation of central GLP1 neurons within the nucleus tractus solitarius and subsequent downstream GLP1 receptor containing circuits may provide a useful tool for controlling food intake