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Recently the frequency of GLP-1 receptor (GLP-1R) agonist based therapy has been increased, particularly in the United States, Europe, and several other nations

This severely biased the study population such that the true risk of developing NAION is likely much lower in a general population

40 (Phase 3), FDA/EMA GLP-1 / GIP / , (Ozempic) (Mounjaro) 40 12 ~24% 48 (Phase 2, NEJM 2023) Mounjaro 15 (~2226%) , : , Phase 3 (Retatrutide) 40 (ALLUVI) 1 - ALLUVI Retatrutide (40 , 10 ), 12 ALLUVI (Dosage Guide) 2.5 10

Capuccio S, Scilletta S, La Rocca F, Miano N, Di Marco M, Bosco G, et al

GTT experiments were performed twice with five or six mice per test article
