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It also suppresses lipid synthesis in the liver

GLP-1 medications can make it challenging to consume adequate protein through whole foods alone, particularly when appetite is suppressed or gastrointestinal side effects such as nausea occur

The shortage led to an increased demand for off-brand versions

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Previously, several FXR agonists have failed in clinical trials, such as obeticholic acid, which was rejected by the FDA in June 2023 due to poor efficacy and significant side effects