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It was used in a once-daily multiple ascending dose phase Ib clinical trial and a 41-day phase IIa trial in overweight and type 2 diabetic patients, and the general safety and tolerability of MEDI0382 were established, as was its placebo-corrected efficacy in reducing fasting blood glucose (1.7 mmol/L), postprandial glucose excursions following a mixed meal test (22.6% area under the curve 04 hours), body weight (2.1 kg), and liver fat (19.6%)
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doi: 10.1007/s13139-021-00723-5 21 BreemanWAde JongMde BloisEBernardBFKonijnenbergMKrenningEP
PKA inhibiting delayed rectifying K + channels lengthen action potentials
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