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J Metab Bariatr Surg 11(2):3948 Aldahash R (2021) Efficacy of glucagon-like peptide-1 receptor agonists in the weight loss among obese individuals: a systematic review

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This Fc domain serves a dual function: it sterically hinders access to DPP-4, thereby protecting the GLP-1 moiety from enzymatic degradation, and it engages the neonatal Fc receptor (FcRn), facilitating receptor-mediated recycling and preventing lysosomal degradation following cellular uptake

Ronald Petersen, a neurologist at the Mayo Clinic in Rochester, Minnesota, who is not involved with the research

Colton Jones, MD, the lead researcher and a hematology and medical oncology fellow at the University of Texas at San Antonio, and colleagues analyzed the health records of nearly 8,800 people with breast cancer and obesity taking both hormonal therapy and GLP-1s