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Yu et al

Nat Metab 2024;6:290303

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2.6 Cytotoxicity studies The cytotoxicity profile of SR18 was examined using the 3-(4,5-dimethylthiazol-2-yl) 2,5-diphenyltetrazolium bromide (MTT) assay utilizing HEK-293 and HeLa cell lines obtained from the School of Biological Sciences, NISER, Bhubaneswar

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These disorders can be associated with insulin resistance, hyperglycemia-induced damage, oxidative stress, astrocyte abnormalities, and mitochondrial dysfunction, resulting in insufficient energy supply, altered synaptic plasticity, death of neuronal cells, as well as functional and structural damage to reward networks