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175 Mitochondrial dysfunction is a defect in the early stage of PD and mainly includes impairment of the mitochondrial electron transport chain, alterations in mitochondrial morphology and dynamics, mutations in mitochondrial DNA, and anomalies in calcium homeostasis, 176 which are closely related to the PD phenotype

The above point (2) provides evidence that loss of GLP-1 secretion with immediate pathophysiological consequences (reduced incretin effect as part of impaired postprandial beta cell function) calls for a replacement therapy with incretin-based glucose-lowering medications [3]

Additionally, uncontrolled hyperglycemia itself causes dry mouth through osmotic diuresis, though semaglutide's glucose-lowering effects should theoretically improve rather than worsen this symptom in patients with diabetes

doi: 10.1038/ajg.2014.427 71 RatzkeC.GoreJ
Recent stories in Science and STAT each shined a spotlight on Mojsovs long-overlooked career, which began at Rockefeller in 1972 when she joined the lab of Nobel Prizewinning biochemist Bruce Merrifield
