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Pharmacokinetics and Tolerability of a Single Dose of Semaglutide, a Human Glucagon-Like Peptide-1 Analog, in Subjects with and without Renal Impairment

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Normal GLP-1 side effects include mild nausea and fullness that typically improve within 48 weeks, while gastroparesis involves persistent symptoms beyond 12 weeks, vomiting of undigested food hours after meals, and severe impairment of nutritional intake requiring objective diagnosis via gastric emptying scintigraphy

Microdosing GLP-1 weight loss drugs like semaglutide is trendy, with supporters touting benefits such as lower costs and potentially fewer side effects