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Description
Some animal studies suggest GLP-1 receptors exist in brain regions involved in stress response, including the hypothalamus and amygdala, raising theoretical possibilities for neuroendocrine modulation
In people with T2D, SUSTAIN-6 revealed increased diabetic-retinopathy complications with semaglutide, primarily in subjects with pre-existing retinopathy and rapid HbA1c reduction 45,46
doi: 10.3390/ijms22105230
These typically improve over 48 weeks
Most patients lose around 5-10 pounds after 12 weeks, though results vary from person to person
Daily totals: 98 grams protein, 31 grams fiber, 1,270 calories
