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In the SURPASS-3 trial, participants had an average T2D duration of 8.4 years, a mean BMI of 33.5 kg/m 2 , and were treated with metformin alone or in combination with an SGLT2 inhibitor

Nausea is one of the most common adverse effects of semaglutide, affecting up to 20-30% of patients, and this can be exacerbated by dental procedures, particularly those involving sedation, antibiotics, or pain medications

Clinical Implications Reaching steady state has important clinical implications

The drug was safe and well-tolerated

Indeed, an emerging body of evidence reviewed below highlights a novel role for central GLP-1 receptor-expressing circuits in regulating the reinforcing efficacy of cocaine and the behavioral mechanisms underlying cocaine taking-and seeking-behaviors

These effects are largely attributable to the drug's action on gastric motility and appetite-regulating pathways