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Exendin-4 regulates the MAPK and WNT signaling pathways to alleviate the osteogenic inhibition of periodontal ligament stem cells in a high glucose environment

Horm Res Paediatr (2021)

While GLP-1 RA drugs are effective, their high cost ( US$1,350/month) and side effects (nausea, stomach pain, heartburn) raise concerns, especially about what happens after stopping treatment

One of the drugs, Zepbound, mimics GLP-1 as well as a hormone called a glucose-dependent insulinotropic polypeptide (GIP), believed to promote the effects of GLP-1

Topline results from the phase III TRIUMPH-1 studyshowed up to 30% weight loss over 104 weeks 20
