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This effect is more pronounced with short-acting GLP-1 agents and tends to diminish over time with long-acting formulations

For example, females under age 44 drove recent growth in GLP-1 options offered by the Smoothie King chain. Though GLP-1 consumers are reducing food and beverage purchases, and their shopping baskets reflect new dietary preferences, theyre still outspending non-users on CPG, Circana noted

This overlap highlights their promise as pharmacological analogues of exercise, and underscores the need for biomarker-driven, disease-specific trials to establish whether GLP-1RAs can deliver durable disease modification across the spectrum of neurodegenerative diseases

However, the long-term sustainability of these effects remains uncertain, as many patients tend to regain weight upon discontinuation of therapy

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Approved for long-term use (more than 12 weeks)