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Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder

Long-term adherence remains high because many patients report improved energy, better blood sugar control, and sustained satietybenefits that extend beyond the number on the scale

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Additionally, they suppress glucagon secretion, a hormone that raises blood glucose levels

Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006

These results demonstrated that tirzepatide 10 and 15 mg had the lowest NNT, where an additional patient achieving the 5% weight reduction threshold would be observed if treating an additional 1.47 and 1.46 patients with tirzepatide 10 and 15 mg, respectively, rather than placebo