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Accordingly, lean mass reduction may represent a context-dependent consequence of sustained energy flux constriction, particularly when anabolic substrate availability and resistance exercise are not proportionately maintained

tirzepatide is contraindicated in individuals with personal or family history of medullary thyroid carcinoma or in patients with multiple endocrine neoplasia type 2 syndromes (54, 61)
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5- other GLP-1 trials in Parkinsons have been statistically negative or the results unclear, 6- the study was conducted in only very early Parkinsons cases, 7- the data, if replicable, may not be generalizable to all GLP-1 agonist drugs or to all subtypes of Parkinsons, and 8- the drug Lixisenatide requires a DAILY injection
Clear expectations improve adherence

Liver enzymes normalize and imaging shows resolved fatty liver
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