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Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study

Smaller meals may also provide less dietary water than before

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Lipid Metabolism In the SURPASS and SURMOUNT phase 3 clinical trial programs (Tables 1 and 2), treatment with tirzepatide was related to an improvement in the lipid profile, with major decreases in triglycerides (Table 4) that cannot be fully accounted for by reductions in weight alone [77]

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