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Healthcare providers typically advise against dropping below 1,200 calories daily for women or 1,500 for men, even with semaglutide, to preserve muscle and prevent nutritional deficiencies

Although the absolute risk is low, clinicians and patients should be aware of these potential sensory changes, as they may influence food preferences, nutrition, and quality of life, Zontag said

This so-called incretin effect is attributed to the insulinotropic action of gut hormones, particularly: Glucose-dependent insulinotropic polypeptide (GIP) Glucagon-like peptide 1 (GLP-1)

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Circulating testosterone concentrations in women with androgen excess may overlap with those of men with androgen deficiency