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A random effects model was selected to perform the meta-analyses, results were expressed as weighted mean differences for continuous outcomes and relative risks for dichotomous outcomes, both with 95% confidence intervals, and with I2 values and P values as markers of heterogeneity

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A systemic review of semaglutide studies found lean mass reductions ranging from negligible to 40% of total weight lost, with larger studies showing more significant losses

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Proglucagon mRNA expression and GLP-1 secretion by cultured human L-cells (NCI-H716) were inhibited following exposure to -carrageenan, a commonly used additive in processed foods