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Titration step values follow the REDEFINE Phase 3 protocol structure as reported by Novo Nordisk and the NEJM publications

The gradual decline in semaglutide levels means that both the therapeutic effects and any side effects will diminish progressively over several weeks rather than stopping abruptly

Typically, dose escalation begins at 0.25mg weekly and increases incrementally to a maximum of 2.4mg if well-tolerated

These are symptoms which may be short-lived and temporary

Although this type of shedding can feel alarming, it is often reversible once the body stabilizes and nutritional balance improves

13.2% placebo), diarrhea (26.9% semaglutide