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74 Therefore, it is necessary to view the risk estimates generated by the PREVENT calculator as an informative tool in shaping discussions about whether specific therapies are appropriate, and the PREVENT risk estimates should not be used in isolation to make intervention decisions

Nonetheless, the specificity of pathways and their contribution has not been fully elucidated, and this underlines the urgency for more comprehensive research

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Cotadutide (MEDI0382) is the most extensively developed dual GLP-1/glucagon receptor agonist, showing significant improvements in glucose control, BW (likely mediated by reduced energy intake rather than increased energy expenditure), hepatic fat, and albuminuria in a small RCT on patients with T2D and overweight or obesity 45,46