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Other putative mechanisms of action of GLP-1 RAs on vascular smooth muscles may include intracellular alterations in activities of protein kinase C, Rho-Kinase, myosin light chain kinase, as well as calcium handling, G-proteins, and ion channels (Xiong et al., 2019)

Tirzepatide compared to semaglutide already showed that dual-receptor agonism outperforms single-receptor activation

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J Biol Chem (2007) 282(14):1016471.10.1074/jbc.M609996200 136 PalakurthiSSAktasHGrubissichLMMortensenRMHalperinJA

Titration Phase: Increase the dose to 0.5 mg once per week for 4 weeks Increase the dose to 1.0 mg once per week for 16 weeks Maintenance Phase: Continue with 1.0 mg once per week indefinitely Remember, altering this weekly dosage without professional advice from our healthcare providers can be detrimental to your health