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Moreover, a retrospective real-world study shows that both GLP1-RA and SGLT-2 inhibitors reduce the 10-year risk for cardiovascular disease in patients with T2D in primary cardiovascular prevention [17], although SGLT-2 inhibitors seem to have a greater cardioprotective benefit compared to GLP-1RA when used for secondary prevention among adults with T2D [18]
18,19 According to recent research, chronic hyperglycemic exposure resulted in compromised BBB integrity, characterized by altered tight junctions, thickened basement membrane, capillary density changes, and pericyte deterioration
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[DOI] [PubMed] [Google Scholar] 139.FDA Approves New Drug Treatment for Chronic Weight Management, First Since 2014|FDA
