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GLP-1s are generally well-tolerated with manageable side effects

Some research shows theres added potential for tirzepatide when its used in conjunction with hormone replacement therapy (HRT)

[DOI] [PubMed] [Google Scholar] 5.Despain D., Hoffman B

Cold Intolerance Some people on GLP1-s report feeling more sensitive to cold temperatures

Our study quantified the running costs in the first 2 years after the initial treatment for both GLP-1 RAs and MBS and found that the mean ongoing costs for GLP-1 RAs over 2 years were $11 689 (nearly 23%) higher than those for MBS
Li Y, Wang Y, Wei Q, et al
