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This makes them more effective than traditional appetite suppressants that rely on stimulatory pathways

For these medications to have the biggest impact on your health and body weight, they should be combined with lifestyle changes like exercise, stress reduction, adequate sleep, and a nutrient-rich diet

The synergistic enhancement theory proposes that GIP and GLP-1 dont just add to each other but actually amplify each others effects

Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures - 2019 update: cosponsored by American Association of Clinical Endocrinologists/American College of Endocrinology, the Obesity Society, American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association, and American Society of Anesthesiologists - executive summary

Because it affects how quickly your stomach empties, it may change how some oral medicines are absorbed

For example, tirzepatide, a dual GLP-1/GIP agonist, has shown promising results in NASH trials
