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Weight gain promotes adipocyte hypertrophy or hyperplasia, driving visceral fat deposition and shifting adipose tissue from an anti-inflammatory, angiogenesis- and lipid storage-favourable state to a proinflammatory phenotype [50]

The first story of this two-part series focused on escaping to the Sierra Madre Occidental mountains inland from Puerto Vallarta, in particular the charming old silver mining town of San Sebastin del Oeste

J Clin Endocrinol Metab 104:47564768 [DOI] [PubMed] [Google Scholar] 35.Paccou J, Tsourdi E, Meier C, Palermo A, Pepe J, Body JJ, Zillikens MC (2022) Bariatric surgery and skeletal health: a narrative review and position statement for management by the European Calcified Tissue Society (ECTS)

5 WARNINGS AND PRECAUTIONS WARNINGS AND PRECAUTIONS SECTION 6 ADVERSE REACTIONS ADVERSE REACTIONS SECTION The following serious adverse reactions are described below or elsewhere in the prescribing information: Risk of Thyroid C-Cell Tumors [see Warnings and Precautions ( 5.1 )] Acute Pancreatitis [see Warnings and Precautions ( 5.2 )] Acute Gallbladder Disease [see Warnings and Precautions ( 5.3 )] Hypoglycemia [see Warnings and Precautions ( 5.4 )] Acute Kidney Injury [see Warnings and Precautions ( 5.5 )] Hypersensitivity Reactions [see Warnings and Precautions ( 5.6 )] Diabetic Retinopathy Complications in Patients with Type 2 Diabetes [see Warnings and Precautions ( 5.7 )] Heart Rate Increase [see Warnings and Precautions ( 5.8 )] Suicidal Behavior and Ideation [see Warnings and Precautions ( 5.9 )] 7 DRUG INTERACTIONS DRUG INTERACTIONS SECTION 8 USE IN SPECIFIC POPULATIONS USE IN SPECIFIC POPULATIONS SECTION 10 OVERDOSAGE OVERDOSAGE SECTION Overdoses have been reported with other GLP-1 receptor agonists