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While receptor identification would facilitate rational design, translational progress may also be achieved through phenotypic approaches that focus on reproducible metabolic outcomes

Efficacy and safety of glucagon-like peptide-1/glucagon receptor co-agonist JNJ-64565111 in individuals with type 2 diabetes mellitus and obesity: a randomized dose-ranging study

JAMA Network Open, 7 (5), e2413172
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Liraglutide was approved without a CVOT (Cardiovascular Outcome Trial) because authorities accepted the results from the LEADER study, designed for superiority

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