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Individual factors, such as starting weight, age, biological sex, sleep, stress, and hormones, all shape how your monthly results unfold

This health coach breaks down the pros and cons of each to help you decide

doi:10.1038/s12276-019-0229-z 22

Med Sci Sports Exerc 40(1):8895 [DOI] [PubMed] [Google Scholar] 31.Sartori R, Romanello V, Sandri M (2021) Mechanisms of muscle atrophy and hypertrophy: implications in health and disease

For patients with type 2 diabetes, a 26-week phase II trial showed that 48% of participants achieved at least 10% weight reduction after treatment with orforglipron 45 mg

Beyond these maximums, additional benefits are unlikely and side effects (nausea, dehydration, pancreatitis risk) increase