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28 This imbalance may allow maximisation of effect on the GIP pathway while minimising GLP-1-related tolerability issues

Other contributing factors include reduced physical activity, poor circulation (peripheral arterial disease), medication interactions , and vitamin or mineral deficiencies (particularly magnesium and vitamin D)

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Magnesium Overview: Magnesium is a vital mineral in numerous bodily functions, including energy production, muscle function, and blood sugar regulation