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While these findings describe the average response, individual responses can vary widely, highlighting the complexity of obesity as a disease

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A 2024 safety review in ScienceDirect noted that tirzepatide may have slightly better GI tolerability than semaglutide, likely because of its dual mechanism ( ScienceDirect , 2024)

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Meal schedule dependent experiment Based on the results, we selected the 1 g/kg dose of Ex which reduced food intake without observable side effects, and went on to investigate the hypothesised meal schedule dependent effects of Ex in all four possible meal schedule conditions (see Fig

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