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The difference becomes more pronounced with higher-dose injectable semaglutide: Wegovy (2.4 mg weekly) demonstrated mean weight loss of approximately 15% of body weight in the STEP clinical trial program for obesity management, substantially exceeding outcomes typically seen with oral semaglutide at diabetes-approved doses

The addition of the glucagon receptor may explain the enhanced weight loss (28.7% vs 17% for sema******, 22.5% for tirzepatide) and the remarkable 86% liver fat reduction observed in trials

Unlike most fat-derived hormones, adiponectin levels tend to decrease with an increase in body fat percentage in adults, linking lower adiponectin concentrations with obesity [27, 29]

[DOI] [PMC free article] [PubMed] [Google Scholar] 7.GLP-1 receptor agonists for the reduction of atherosclerotic cardiovascular risk in patients with type 2 diabetes

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