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GLP-1 diabetes and weight-loss drug side effects

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Together, these variants influence baseline hunger drive, medication absorption, metabolic rate, and whether your body responds better to a GLP-1 agonist alone or a dual-mechanism therapy combining GLP-1 and GIP signaling

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Diabetes Care 36 , 40224029 (2013)

For comparison with published CNS GIPR KO models 18 and CNS GLP-1R KO models 19,20 , Gipr Syn/ mice were further characterized in two independent cohorts (Extended Data Fig