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Some plans require 3-6 months of documented prior attempts

31 Clinical Practice Guidelines suggest that a daily reduction in energy intake of 2.6 MJ will predict a weight loss of about 0.5 kg weekly (assuming no change in EE)

Cost-effectiveness assessments demonstrate significant variability across healthcare systems and patient demographics

Final conclusions regarding overall safety will depend on the results of long-term Phase 3 data

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Another study found that most patients were not able to continue GLP-1s within a year of initiation, with higher discontinuation rates among those without diabetes
