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the reduced lateral diffusion of GLP-1R V229A could therefore be due to the mutant receptor existing as a subpopulation of pre-clustered, higher order oligomeric assemblies in absence of agonist stimulation, predicted to cause a decrease in the movement of these clusters and potentially hinder cholesterol binding

These benefits appear to extend even to people without diabetes who have a history of cardiovascular disease

For researchers and institutions: Mandate sex- and hormone-state reporting in trials of diabetes therapies and require pre-specified subgroup analyses

Consult a physician before using any GLP-1-activating compound
