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This distinction is particularly important given the wellestablished bidirectional relationship between diabetes and depression, wherein poor glycaemic control can exacerbate depressive symptoms, and depression can impair diabetes selfmanagement

It may be a promising way to control T2DM because it can relieve T2DM through different mechanisms and ways of action, including antimicrobial and anti-inflammatory, protecting the intestinal barrier function, improving microbial metabolism, stabilizing intestinal hormones, and so on

EX4 markedly stimulated glucagon secretion (Fig