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In this process, the expression of orexigenic POMC is upregulated, whereas the anorexigenic AgRP and NPY are repressed, leading to reduced food intake and increased energy expenditure [91], [92], [93]

These steps address the underlying cause (dryness and dehydration) rather than treating itching as an independent symptom

Keep 3-6 months of medication costs in emergency savings

Most patients notice appetite returning within 2-4 weeks of stopping

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GLP-1 dose conversion FAQs Can I switch from a daily GLP-1 to a weekly one