side effects of coming off glp 1 Eating Well on Your GLP-1 Journey: A Guide for Maximizing Results and Minimizing When to Pause or Stop

These adverse events lead some patients to discontinue therapy before achieving optimal clinical outcomes, reducing long-term treatment adherence

However, gradual dose reduction and lifestyle reinforcement can spread this timeline significantly and minimize total rebound

While this side effect wasnt recognised in initial clinical trials of weight loss drugs, widespread use of them has revealed this correlation

Research consistently shows that people who maintain 150 minutes of moderate aerobic activity weekly plus 23 sessions of resistance training regain less weight and experience fewer hunger surges

Indeed, early retrospective cohort studies and post-hoc analyses suggested that GLP-1RAs might delay DR progression or improve outcomes, with one study reporting that 80% of patients on continuous therapy achieved either improvement or stabilization of their DR status [78, 79]

Initially, the research focused on treating diabetes and cardiovascular diseases (9,10,17,18)