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joint position sense was absent in the toes and ankles and reduced in the fingers

Chronic hyperglycemia and hyperinsulinemia drive a metabolic imbalance promoting oxidative stress, inflammation, and endothelial damage, responsible for non-enzymatic biomolecule glycation, accelerating cerebrovascular atherosclerosis and neurodegenerative damage that further promote cognitive dysfunction and dementia (Kopp et al., 2022)

Physiological Reviews, 2012

Oral therapy for acute diarrhea

New England Journal of Medicine, 384 (11), 9891002.

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